My reaction is similar to Larimore's: I think this makes Clinton look more appealing, not less. But my reason is a little different from Larimore. She thinks it may lead people to feel a little sorry for Clinton:
I feel for her. No one likes to see pictures of themselves having a bad hair day, or after missing a few trips to the gym. And that's without the fate of a presidential campaign — her life's ambition — hanging precariously in the balance.
I think it just makes her look more down-to-earth: Less carefully put together and more lived-in, an older professional woman on whom time has taken its toll — as it does on us all — but who has acquired the advantages of experience in exchange. I still won't vote for her, for reasons entirely unrelated to her appearance; but I like the photo. Ann Althouse has more.